Conclusion: The study on the treatment Loseke 40 mg iv, the drug was administered 3 hours before the start of the study. Notes the effective action of the drug for 15 hours, zones of acid production in pH> 4 observed 87% of time pH> 6-78% of the time. Period giperatsidnyh observed at the end of the drug lasting about 3 hours. In antral alkalinization compensation 69% of the time of the study.
It should be noted that hydrochloric brand viagra online acid and pepsin in the bleeding has developed to inhibit clot formation and cause lysis of already formed blood clots. Vascular-platelet hemostasis occurs only at pH ? 6. Therefore, the goal of antisecretory therapy in patients with HMC - to maintain pH ? 6 in the stomach for 80% of the time of day. We compared the nature of gastric secretion in patients with high risk of rebleeding against anisekretornoy therapy of H2-blockers and proton pump inhibitors (Figs. 4, 5).
Conclusion: The study on the treatment zantakom 40mg x 2 times / in the drug was administered at 19.00, giperatsidnyh celebrated throughout the night of the study period, in areas of acid production pH> 4 observed only 27.3% of the time studies, pH <6-86% of the time. Effect of the drug is ineffective.
As can be seen on the presented pH-grams, the use of proton pump inhibitors can maintain a pH> 6 in the stomach over 78% of the time of the study even after a single dose, and the generic viagra use of H2-blockers - no. It was probably connected with it a greater number of recurrences of gastrointestinal bleeding on the background of antisecretory therapy of H2-blockers in the period 1990-2000.
The number of recurrent hemorrhages in patients over age group during treatment with proton pump inhibitors was reduced in 2,5 times - 13 (28,3%) - compared to the time period 1990-2000. - 33 (61,7%) (Fig. 6).
It is believed that the recurrence of bleeding in elderly patients, firstly, associated with reduced elasticity of the vascular wall due to atherosclerosis, and secondly, on the nature of antisecretory therapy [45, 89; 166; 195]. In our study, these provisions have been confirmed: 8 out of 46 patients with recurrent bleeding was pronounced brand name levitra atherosclerosis, all of these ulcers were located in the body and subkardialnom of the stomach. 42 (68,8%) patients with recurrent bleeding received antisecretory therapy with injectable forms of N, - blockers and 19 (31.2%) had received antisecretory therapy with injectable forms of proton pump inhibitors.
Recurrence of bleeding ulcers in the stomach is an absolute indication for surgical treatment, all of rebleeding from gastric ulcers developed in the first three days of admission to the clinic and were associated with inadequate endoscopic hemostasis or misjudgment of the risk of rebleeding. If in 1990-2000. operated on 19 (76%) of patients with recurrent bleeding from duodenal ulcers, in 2001 - 2008. operated 4 (40%) of 10 patients. 6 patients treated conservatively. Rebleeding in all cases was stopped endoscopically. Patients were cialis without prescription assigned to inject the form of proton pump inhibitors.
Most critical for the occurrence of rebleeding from ulcers are the first 6 days of treatment, recurrence of bleeding during this time frame occurred in 44 (95%) of 46 patients. Rebleeding in the first three days in 10 elderly patients was associated with inadequate endoscopic hemostasis and initial misjudgment of the risk of rebleeding. Rebleeding in 4-day 6 was 34 patients. It should be noted that these days are critical for the treatment of ulcer bleeding, as it was at this time there is lysis of thrombus within a lesion [67, 96; 101]. Elderly patients with recurrent bleeding was associated with decompensation of comorbidity and the growth of OPA, which is associated with the reaction of the organism to blood loss. 23 of 34 elderly patients were operated. 11 patients in this group of rebleeding were associated with generic levitra inadequate antisecretory therapy, all patients received injectable forms of H2-blockers, they had changed the regime of antisecretory therapy and underwent endoscopic hemostasis. Outcome favorable repeated recurrence of bleeding was not.
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